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KMID : 0369819920220040251
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 4 p.251 ~ p.266
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Hydrogels for Drug Delivery System : Colon - Specific Delivery
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박기동/Park KD
정서영/김영하/Jeong SY/Kim YH
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Abstract
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A major problem with the peptide-based drugs is that these drugs must generally be administered by injection. Therefore, there is considerable research interest in alternative routes of delivery, such as buccal, nasal, gastrointestinal route and etc. Site-specific drug delivery to the colon, as an alternative to parenteral drug delivery, is of interest for the delivery of peptide-based drugs as well as the delivery of low molecular weight drugs for the treatment of colonic disease, This review describes some considerations of colon-specific drug delivery using hydrogels.
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KEYWORD
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Hydrogels, Colon-specific delivery, Biodegradable hydrogels, Stimuli-sensitive hydrogels
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